【低钠血症可反映SLE………】

低钠血症可反映系统性红斑狼疮患者的疾病活动和炎症

作者：Il ShinJ，et al. 翻译：北医三院刘胜宝（liushegnbao2@163.com）
发布者：于若寒，校正：刘佩玲
摘要:本研究的目的是要确定是否低钠血症与SLE疾病活动相关联。我们回顾性分析了两个中心的对立队列的儿童和成人SLE患者的数据。在儿童ＳＬＥ患者中低钠血症与血氯（P = 0.004），白蛋白（P = 0.002）和系统性红斑狼疮疾病活动指数（SLEDAI）（P = 0.026）有关。低钠血症在儿童ＳＬＥ患者中，与ESR负相关（p = 0.001）和血清白蛋白水平（P <0.0001）及C3（p值= 0.008）呈正相关；在成年ＳＬＥ患者中与血清IL-6水平呈负相关（p值= 0.003）。在儿童ＳＬＥ患者中， C3水平减低（OR 1.069，P = 0.031），血氯减低（OR 2.054，P = 0.006），红细胞沉降率（ESR）增加（OR 1.066，P = 0.03）是低钠血症的独立危险因素；我们的研究首次表明，低钠血症可能反映疾病活动与SLE的严重炎症。
附原文：Theaim of this study was to determine whether decreased serum sodium concentrationcould be associated with the disease activity in SLE.We retrospectively analyzed the data of the two independent cohorts of childrenand adults with SLE in two centers. Hyponatremiawas associated with serum chloride (p = 0.004), albumin (p = 0.002) and SLE disease activity index (SLEDAI) (p = 0.026) inchildren with SLE. Serum sodium levels werecorrelated negatively with ESR (p =0.001) and positively with serum albumin levels(p < 0.0001) and C3 (p = 0.008) in children with SLEand those levels were correlated negatively with serum interleukin-6 levels(p = 0.003) in adults with SLE. Independent riskfactors for the development of hyponatremia were the decreased serum C3 levels(OR 1.069, p = 0.031), the decreased serum chloride levels (OR 2.054,p = 0.006) and increased erythrocyte sedimentation rate (ESR) (OR 1.066,p = 0.03) in children with SLE and increasedC-reactive protein (CRP) (OR 1.480, p = 0.023) in combined cohorts with SLE by multiple logistic regression analyses. Our studyfirstly showed that hyponatremia could reflect a disease activity and severe inflammation of SLE.
引自：IL SHIN J, PARK S J, SUH C H, et al. Hyponatremia in patients with systemic lupus erythematosus [J]. Scientific reports, 2016, 6:25566.