化疗方法治疗红斑狼疮（part 3,环磷酰胺）

Cytoxan

The last main chemotherapy medication lupus patients may take is Cytoxan. It is typically used to treat leukemia, ovarian cancer, neuroblastoma, eye cancer and breast cancer, in addition to rheumatologic diseases.

环磷酰胺
最后一种主要用来治疗狼疮患者的化疗药物是环磷酰胺。它通常也用于治疗白血病、卵巢癌、神经母细胞瘤,眼癌和乳腺癌,以及其它风湿类疾病。

It is typically taken in the form of a shot and is used to treat more severe and serious types of lupus by lowering the immune system’s activity. Cancer patients take Cytoxan in combination with other medication and at a higher dose than lupus patients.

它通常采用注射的方式从而通过降低免疫系统的活动来治疗更严重和严重类型的红斑狼疮。癌症患者接受环磷酰胺的治疗并联合其他药物，其使用的剂量会高于狼疮病人。

Cytoxan may make it more difficult for wounds to heal and patients may find they bruise a lot more easily than they did before taking the medication. It is not recommended to participate in activities that may induce injuries.

环磷酰胺可能伤口愈合更加困难，而且病人可能会发现他们比以前更容易瘀伤，对比以前服用的药物。不建议参与任何可能引起损伤的活动。

As with the other chemo medications, there is a risk of developing a serious infection. Thus, patients are advised to tell their doctor if they notice any symptoms out of the ordinary, particularly chills or fever. It is also not recommended that pregnant or breastfeeding women take Cytoxan. Common side effects of Cytoxan may include:

与其他化疗药物一样,服用此药会有患严重感染的风险。因此,建议病人要及时告诉医生，如果他们发现任何不寻常的症状,尤其是发冷或发烧。也不建议怀孕或哺乳妇女服用环磷酰胺。常见的副作用可能包括：

Loss of menstrual period Hair loss (though rarely full hair loss for lupus patients) Appetite loss Pale skin Diarrhea Vomiting Feeling generally unwell Skin rash Stomach pain Weakness

闭经
脱发(虽然很少在狼疮患者全部脱发)
食欲丧失
皮肤苍白
腹泻呕吐
总体感觉不好
皮疹
胃痛
体弱
指甲的颜色和纹理有变化

While an option for those who have severe lupus symptoms, chemotherapy is never the first option and always done after other methods have proved ineffective.

做为那些有严重的红斑狼疮症状的一种治疗方案，化疗永远不是第一个选择,其使用总是要在其他方法被证明是无效的之后的。