【膳食营养素可能在狼疮……】

膳食营养素可能在狼疮动脉粥样硬化中发挥作用

作者：Lourdudoss C，et al. 翻译：北医三院刘艳艳 <420518527@qq.com>
发布者：于若寒，校正：刘佩玲

摘要: 目的：探讨膳食中微量营养素的摄入量在系统性红斑狼疮（SLE）中的作用。

方法：这项研究入组了111例SLE患者和118名在年龄和性别上与之匹配的对照组。将饮食的数据（食物频率问卷）与SLE活动性测量、系统性红斑狼疮疾病活动指数（SLEDAI）及颈动脉粥样硬化/无回声斑块（B超）的数据进行分析。在SLE组和对照组之间进行膳食微量营养素摄入量的比较，并研究膳食微量营养素的摄于量与狼疮活动度及动脉粥样硬化的关系。在调整潜在的混杂因素后通过Logistic回归分析，明确微量营养素的摄入量和斑块之间的关系。

结果：除了磷与SLEDAI＞6之间有关，微量营养素摄入量在SLE患者组和对照组、较低和较高的狼疮活动度之间没有差异。在SLE患者中，一些微量营养素与左侧动脉粥样硬化斑块有关。较少的维生素B2和磷的摄入与左侧动脉粥样硬化斑块有关（分别是OR 3.06 95%CI 1.12-8.40、OR 4.36 95%CI 1.53-12.39）。较多的硒、维生素B1的摄入与左侧动脉粥样硬化斑块呈负相关（分别是 OR 0.28 95% CI 0.09-0.89、OR 0.26 95% CI 0.08-0.80）。此外，较多的维生素B1摄入量与左侧无回声斑块呈负相关（OR 0.22，95% CI 0.06-0.84）。较少的叶酸摄入量与双侧的无回声斑块呈负相关（OR 0.36，95% CI 0.13-0.99）。

结论：膳食微量营养素的摄入量在SLE患者组和对照组之间无差别。磷与狼疮活动有关。维生素B2、磷、硒和维生素B1与SLE患者左侧动脉粥样硬化斑块呈负相关，但在对照组无相关性。膳食营养素可能在SLE动脉粥样硬化中发挥作用。

附原文：Abstract OBJECTIVE:The aim of this study was to investigate the role of dietary micronutrient intake in systemic lupus erythematosus (SLE).METHODS:This study included 111 SLE patients and 118 age and gender-matched controls. Data on diet (food frequency questionnaires) were linked with data on Systemic Lupus Activity Measure, Systemic Lupus Erythematosus Disease Activity Index (SLEDAI) and carotid atherosclerotic/echolucent plaque (B-mode ultrasound). Dietary micronutrient intake were compared between SLE patients and controls and in relation to lupus activity and atherosclerosis in SLE. Associations between micronutrient intake and plaque were analyzed through logistic regression, adjusted for potential confounders.RESULTS: Micronutrient intake did not differ between patients and controls, and between lower and higher lupus activity, apart from the fact that phosphorus was associated with SLEDAI > 6. In SLE patients, some micronutrients were associated with atherosclerotic plaque, left side. Lower intake of riboflavin and phosphorus was associated with atherosclerotic plaque, left side (odds ratio (OR) 3.06, 95% confidence interval (CI) 1.12-8.40 and OR 4.36, 95% CI 1.53-12.39, respectively). Higher intake of selenium and thiamin was inversely associated with atherosclerotic plaque, left side (OR 0.28, 95% CI 0.09-0.89 and OR 0.26, 95% CI 0.08-0.80, respectively). In addition, higher intake of thiamin was inversely associated with echolucent plaque, left side (OR 0.22, 95% CI 0.06-0.84). Lower intake of folate was inversely associated with bilateral echolucent plaque (OR 0.36, 95% CI 0.13-0.99).CONCLUSIONS: SLE patients did not have different dietary micronutrient intake compared to controls. Phosphorus was associated with lupus activity. Riboflavin, phosphorus, selenium and thiamin were inversely associated with atherosclerotic plaque, left side in SLE patients, but not in controls. Dietary micronutrients may play a role in atherosclerosis in SLE.
引自：Lourdudoss C, Elkan AC, Hafström I, Jogestrand T, Gustafsson T, van Vollenhoven R, Frostegård J. Dietary micronutrient intake and atherosclerosis in systemic lupus erythematosus. Lupus. 2016 Jun 22.