霉酚酸酯（MMF）

进展丨霉酚酸酯（MMF）成功治疗严重难治性狼疮性肝炎1例

摘要
与系统性红斑狼疮相关的肝炎，称为狼疮性肝炎，是系统性红斑狼疮的一种少见表现，通常是亚临床血清肝酶的轻度异常。虽然临床上显著的和难治性狼疮性肝炎的病例是罕见的，但是也要明确狼疮性肝炎的治疗方案。

在这里，我们报告一名45岁的男子进行性狼疮性肝炎并发自身免疫性溶血性贫血的病例。该患者狼疮性肝炎经过他克莫司、硫唑嘌呤和环磷酰胺治疗效果不好，但霉酚酸酯治疗成功。因此霉酚酸酯治疗狼疮性肝炎可能是一种有效的治疗选择。

附原文

Abstract：Systemic lupus erythematosus-related hepatitis,known as lupus hepatitis, is a rare manifestation of systemic lupus erythematosus, and is usually subclinical with mild abnormalities of serum liver enzymes. While cases with clinically significant and refractory lupus hepatitis are uncommon, treatment options for lupus hepatitis are to be established. Here, we report the case of a 45-year-old man with progressive lupus hepatitis accompanied by autoimmune haemolytic anaemia.Lupus hepatitis of this patient was refractory to tacrolimus, azathioprine and cyclophosphamide, but was successfully treated by mycophenolate mofetil.Mycophenolate mofetil might be an effective therapeutic option for refractory lupus hepatitis.
作者：Tagawa Y,et al.
来源：中国风湿病公众论坛
引自：Tagawa Y,et al. Successful treatment of severe refractory lupus hepatitis with mycophenolate mofetil . Lupus, 2016,25(5):543-6.