来氟米特

Leflunomide (Arava)

Leflunomide is another DMARD used to treat the swelling, pain, and stiffness that many lupus patients feel due to arthritis. It can either be prescribed alone or in combination with other treatments, such as methotrexate; often leflunomide is prescribed for patients who do not respond well to methotrexate. Leflunomide works by blocking the formation of DNA in the cells of your body, including those of the immune system. In hindering the formation of DNA, leflunomide stops the body from producing the overactive immune cells that are responsible for the swelling, stiffness, and pain in your joints.

Leflunomide(Arava)

来氟米特是另一种DMARD(抗风湿病的缓解药药物），用于治疗许多狼疮患者的关节炎引起的肿胀、疼痛和僵硬,它可以单独使用或结合其他药物,如甲氨蝶呤;来氟米特常常是在甲氨蝶呤对病人没有作用时使用。来氟米特是通过阻断体内那些包含免疫系统的细胞的DNA合成来工作的。通过阻碍DNA的形成,leflunomide阻止体内产生过度的免疫细胞,而就是这些免疫细胞引起了肿胀,关节僵硬和疼痛。

Leflunomide is usually taken in tablets of 10 or 20 milligrams (mg) once a day. 6-12 weeks may pass before you feel the full benefits of this medication, although your joint pain and stiffness will probably start to improve after just a few weeks. It takes some time for the medication to build up in your body, so some doctors may prescribe something called a “loading dose” when you first begin to take leflunomide. A loading dose is a large dose—about 100 mg—usually given once a week for three weeks in addition to your regular dose. Alternatively, some doctors may give this loading dose over the first three days. This technique, however, usually increases the chance that the person will develop side effects, including diarrhea. The good news is that the diarrhea usually goes away once the loading dose is stopped.



Leflunomide通常是片剂10或20毫克(mg)一天一次。尽管可能你的关节疼痛和僵硬几周后可能会开始改善，6 - 12周后你才感觉这个药物的全部作用。此药物在你的身体里建立起防御系统是需要一定的时间的，所以当你第一次开始使用来氟米特时一些医生可能会开一个叫做“负荷剂量”，负荷剂量是一个大剂量，大约100 mg，除常规剂量外给出一周一次持续三个星期。另外,一些医生可能会在前三天给出这个负荷剂量然而,这种服用方法通常增加副作用,包括腹泻。好消息是,一旦负荷剂量停了下来腹泻通常会消失。