考虑用化疗方式治疗SLE （part 1)

本文转载于北美SLE 论坛杂志《2015最受欢迎关于狼疮的十大文章》之一，译文由本人翻译，意在让国内伙伴更加了解化疗药物用于红斑狼疮治疗在北美的使用情况，不当之处请见谅。
Considering Chemotherapy for Treating Lupus When you hear the word “chemotherapy,” most people think of a particularly potent cancer treatment. While they aren’t wrong, chemotherapy can also be used to treat lupus, which many people heard about for the first time when actress and singer Selena Gomez told the press she received chemo treatment for her lupus.
考虑化疗方法治疗狼疮
当你听到这个词“化疗”,大多数人认为这是一个特别有效的癌症治疗方法。他们当然没有错,化疗也可以用于治疗红斑狼疮,许多人是第一次听说，当演员和歌手赛琳娜·戈麦斯告诉记者她接受化疗方法治疗她的红斑狼疮。
Chemotherapy is typically reserved for more aggressive forms of lupus and may be taken over the course of several months.
化疗通常用来治疗更激进形式的红斑狼疮而且要经历几个月的时间。
There are three major chemo medications for lupus that are given to patients.
有三种主要化疗药物用于治疗红斑狼疮病人。
CellCept Mycophenolate mofetil (commonly known as CellCept) was originally created for recent organ transplant recipients. CellCept works by lowering the immune system (thus making it work for lupus patients whose immune system is in overdrive), and for its original purpose, helps a patient’s body adapt to a new organ and not reject it. The dose a patient receives depends on the severity of their lupus and it may be taken in conjunction with a steroid to stabilize the patient even further.
骁悉霉酚酸酯(俗称骁悉)，最初研发此药是用于刚刚接受器官移植的病人。骁悉对于狼疮病人的作用是用于降低免疫系统(因为狼疮病人的免疫系统是超负荷的工作),而其原来的作用,是帮助病人的身体适应一个新的器官,而不是拒绝它。一个病人接受的剂量取决于他们狼疮的严重程度且可能配合已经使用的类固醇来进一步稳定病人的病情。
Though most people think of hair loss as the number one side effect of chemotherapy, the drugs given to lupus patients do not typically make patients lose their hair. Instead, lupus itself and other treatments for lupus can cause hair thinning and loss, though no two people with lupus suffer the exact same symptoms.
尽管大多数人认为脱发是化疗的副作用之一，但其实给狼疮患者这个药物通常不让患者脱发。相反,狼疮本身和其他治疗红斑狼疮的药物会导致头发稀疏和损失, 尽管从来没有两个狼疮患者遭受同样的症状。
Instead, those taking CellCept may notice other side effects: Nausea Headache Vomiting Gas Diarrhea Loss of appetite Stomach upset Tremor Insomnia Anxiety Numbness and tingling feeling Swelling in the hands and feet
取而代之的,服用骁悉后可能会注意到其他的副作用:
恶心，头痛，呕吐，胀气，腹泻，食欲不振，胃部不适，震颤，失眠，焦虑，感到麻木和刺痛，感觉手脚肿胀。
Because of the strength of this medication, it is not recommended that pregnant women take it. In fact, it is required that women have a negative pregnancy test before undergoing treatment with CellCept and should not attempt pregnancy for six weeks after ceasing the medication.
因为这种药的效果,不建议孕妇服用。事实上,在接受骁悉治疗之前，必需保证女性的怀孕测试是阴性的,且停止药物治疗六周之内不可以怀孕。
The most common serious side effect is infection, which you must notify your doctor of immediately if you begin to notice the signs of one as this may become life-threatening. Many doctors will ask that patients take regular blood tests to ensure the CellCept is not doing further damage to the body.
最常见的严重的副作用是感染,如果你注意到有感染的迹象时你必须立即通知你的医生,这可能是致命的。许多医生会要求病人做常规血液检查,确保骁悉对身体没有进一步的损害。
Patients taking CellCept for lupus may have to wait several months to notice big changes to their health or to be able to tell if they are benefitting from the drug. There is also a suggestion that people who take CellCept may be at a higher risk for developing cancer, however people who need to take it may already be in the pool of “increased risk” before they even begin the chemotherapy.
对于红斑狼疮病人服用骁悉后可能要等几个月才注意到对他们的健康状况有大的改变或者才能够判断他们是否受益于药物。另外还有一种意见是说，服用骁悉的患者可能罹患癌症的风险更高,但是其实需要的人可能已经处于＂加剧风险＂的池子中了，在这之前他们甚至早就开始化疗了。
It is also recommended that patients who take CellCept wear sunscreen and avoid prolonged sun exposure, however if you’re already a lupus patient, you’ve likely already got that one covered. It is also important you attend and keep all regularly scheduled appointments with your doctor as this medication is particularly strong.
也建议服用骁悉的患者要涂抹防晒霜,避免长时间的阳光照射,但是如果你已经是狼疮病人,你可能已经对阳光有防范了。同样重要的是你必须按时并保持所有定期医生回访复查,因为这药物的药效强烈。

Next page: using Methotrexate and Cytoxan for lupus treatment
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