单纯精神神经性狼疮患者的妊娠……

前沿进展丨单纯精神神经性狼疮患者的妊娠结局相对乐观

作者：GR de Jesus，et al
译者：李欣艺
发布：郭 越 校对：王振青
摘要


此研究旨在分析妊娠的神经精神狼疮患者母体与胎儿的结局。此研究从135例妊娠患者中筛选出26例患者，其均为2011-2015年就诊、既往和/或存在活动性神经精神狼疮患者。26例患者中3例在怀孕时存在活动性神经精神狼疮，但只有1例在孕期时仍存在病情活动，主要原因在于该患者未按时用药。26%新生儿相对于妊娠周数来说都是低体重的，40%属于早产，无新生儿死亡情况或者早熟等并发症发生。9例患者出现先兆子痫，其中2例因病情重出现胎儿胎死宫内。与无此疾病的狼疮患者相比，神经精神性狼疮患者的胎儿早熟及先兆子痫的发生率相对较高。然而，当除去同时伴有狼疮肾炎的神经精神狼疮患者，单纯神经精神性狼疮患者的妊娠结局还是比较好的。




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附原文：

Abstract：
This study analyzed maternal and fetaloutcomes of pregnancies of neuropsychiatric systemic lupus erythematosuspatients followed in a reference unit. This retrospective cohort study included26 pregnancies of patients seen between 2011 and 2015 included with historyand/or active neuropsychiatric systemic lupus erythematosus among 135pregnancies. Three patients had active neuropsychiatric systemic lupuserythematosus at conception, but only one remained with neurological activityduring gestation, characteristically related to the inadvertent suspension ofmedications. Twenty six percent of the newborns were small for gestational ageand 40% of live births were premature, with no neonatal death or earlycomplications of prematurity. Preeclampsia was diagnosed in nine pregnancies,with two cases of early severe form that resulted in intrauterine fetal death.Patients with neuropsychiatric systemic
lupus erythematosus had moreprematurity and preeclampsia compared to patients without neuropsychiatricdisease. However, when concomitant lupus nephritis was excluded, thegestational results of neuropsychiatric systemic lupus erythematosus patientswere more favorable.






引自：
GR de Jesus1 , BCRodrigues2 , MI Lacerda2 , FC dos Santos1 , NR de Jesus1 , EM Klumb2 and RA Levy2.Gestational outcomes in patientswith neuropsychiatric systemic lupus rythematosus Lupus (2017) 26, 537–542.