睡眠障碍与系统性红斑狼疮

　　系统性红斑狼疮（SLE）等风湿性疾病中常发生睡眠功能紊乱。但是SLE中睡眠紊乱的发生率及其形成的原因未知。因此意大利比萨大学的Palagini L等人最近结合已有的临床和生物心理学数据分析睡眠障碍和SLE之间的关系，并对这一情况进行了综述。

　　他们在MEDLINE， EMBASE和PsychINFO数据库中使用MeSH主题词对“sleep disorders”和“SLE”的标题和关键字进行系统检索。最终共检出9篇报道睡眠障碍和SLE关系文章。他们发现睡眠障碍的发生率为55%到85%；变异主要是由于结果评估方式不同。同时大多数研究都报道了睡眠障碍与疾病活动性、疼痛和疲劳之间的关系。因此假定社会心理学变化、抑郁、甾族化合物药物的使用以及睡眠障碍对痛觉、炎症和细胞因子为生物心理学学因素。

　　50%以上的SLE患者出现睡眠功能紊乱，发生率与疾病活动性有关。疼痛和疲与睡眠障碍相关。在各种有关睡眠障碍与SLE关系的假设中，社会心理/心理因素特别是抑郁的导致其发生的可能性特别大。

　　原文阅读：Sleep disorders and systemic lupus erythematosus.

　　Abstract

　　Objective Sleep disturbances are often seen in rheumatic diseases， including systemic lupus erythematosus （SLE）。 However， the prevalence of sleep disorders in SLE as well as the contributing factors to their occurrence remain poorly understood. The aim of this paper is to review the clinical and psychobiological data on the relationship between sleep disturbances and SLE. Method We performed a systematic search of MEDLINE， EMBASE and PsychINFO， using MeSH headings and keywords for “sleep disorders” and “SLE.” Results Nine studies reporting the relationship between sleep disorders and SLE were found. Prevalence rates of sleep disorders ranged between 55% and 85%; differences in assessment techniques appeared to be a major source of this variability. In the majority of the studies an association between sleep disorders and disease activity， pain and fatigue has been reported. Psychosocial variables， depression， steroid use， and the role that sleep disruption has on pain， inflammation and cytokines， have been hypothesized as possible psychobiological factors. Conclusions Sleep disorders appear to occur in more than half of patients with SLE and appear to be associated with disease activity. Pain and fatigue are also related to sleep disorders. Among the hypotheses on the possible mechanisms underlining the association between sleep disorders and SLE， psychosocial/psychological factors， especially