科学家发现如何“关掉”自身免疫性疾病的开关

小便 小便 2016-08-10 10:16:0811214阅读


材料来源:

英国布里斯托大学

翻译:脑洞病人(翻译志愿者)


摘要:


科学家在攻克免疫疾病如多发性硬皮病的道路上取得突破性进展——揭露如何组织细胞攻击健康的身体组织。除了身体免疫系统出现错误,攻击自身组织之外,研究人员还发现了如何将攻击性细胞转化为保护性细胞,从而抵抗外界病毒。


治疗的目标的是将可能引起自身免疫问题的攻击性细胞转化为抵抗疾病的保护性细胞。




(图片文字翻译:侵略者细胞是最有可能导致自身免疫性疾病的细胞,针对性的治疗导致这些细胞转化为保护细胞,从而使基因的表达在治疗者的各阶段变化,在这一系列的地图变化如图所示

来源:布里斯托大学Bronwen Burton博士   本段文字由“风吹过来你的样子"志愿者翻译)




正如热图中的颜色变化所示,每个治疗阶段的基因表达都会有所变化。


图表来源:英国布里斯托大学



科学家在攻克免疫疾病如多发性硬皮病的道路上取得突破性进展——揭露如何组织细胞攻击健康的身体组织。除了身体免疫系统出现错误,攻击自身组织之外,研究人员还发现了如何将攻击性细胞转化为保护性细胞,从而抵抗外界病毒。


该研究由维康信赞助,发表于 Nature Communications


该项最新发现有望使抗原-特效药免疫疗法广泛应用于治疗多种免疫疾病如 多发性硬皮病、一型糖尿病、甲状腺自体免疫疾病和系统性红斑狼疮等。


仅仅在英国,就有100000名多发性硬皮病患者,而全球患者更是有250万名之多。


科学家能有选择性的针对引起自身免疫疾病的细胞,减缓其对自身组织攻击的同时将其转化为外来病毒的保护性细胞。


在此之前,该转化被应用于过敏症,被称之为退敏感作用。但是退敏感作用在自身免疫疾病方面的应用,最近才被提出。


英国布里斯托研究组织发现蛋白质碎片的处理是关键之处,因为细胞的错误攻击导致了免疫应答的纠正。


更重要的是,该研究发现逐渐提高抗原碎片的注射剂量能够达到有效治疗的目的。


为了找出该免疫疗法的治疗机制,科学家深入研究免疫细胞的基因和蛋白质,试图找出自身免疫的开关


研究者发现,基因表达的改变能帮助解释有效治疗能使攻击性细胞转化为保护性细胞。凭借个体免疫系统忽略自身组织同时全面防护外界感染,从而恢复细胞的自身耐受性。


通过明确区分攻击性细胞,该免疫疗法能够避免使用免疫抑制剂所带来的副作用,如感染,肿瘤以及对身体自然调整机制的破坏。


研究小组负责人David Wraith 教授表示,关于分子在抗原-特效药免疫疗法中的深刻见解,在治疗方案的选择上提供了新的机会 ,同时为监控有效治疗提供了有效标记物。这些发现对饱受免疫问题却难以治疗的病人有重要意义。


据英国布里斯托大学透露,这个可能提高全球数百万人的生活质量的治疗方法目前由A 生物技术公司进行临床试验


资料来源:

上述材料摘自英国布里斯托大学资料。根据内容和长度,材料内容有所删减。



Scientists discover how to 'switch off' autoimmune diseases


Source:

University of Bristol

Summary:

Scientists have made an important breakthrough in the fight against debilitating autoimmune diseases such as multiple sclerosis by revealing how to stop cells attacking healthy body tissue. Rather than the body's immune system destroying its own tissue by mistake, researchers have discovered how cells convert from being aggressive to actually protecting against disease.


Aggressor cells, which have the potential to cause autoimmunity, are targeted by treatment, causing conversion of these cells to protector cells. Gene expression changes gradually at each stage of treatment, as illustrated by the color changes in this series of heat maps.

Credit: University of Bristol/Dr. Bronwen Burton

Scientists have made an important breakthrough in the fight against debilitating autoimmune diseases such as multiple sclerosis by revealing how to stop cells attacking healthy body tissue.

Rather than the body's immune system destroying its own tissue by mistake, researchers at the University of Bristol have discovered how cells convert from being aggressive to actually protecting against disease.

The study, funded by the Wellcome Trust, is published in Nature Communications.

It's hoped this latest insight will lead to the widespread use of antigen-specific immunotherapy as a treatment for many autoimmune disorders, including multiple sclerosis (MS), type 1 diabetes, Graves' disease and systemic lupus erythematosus (SLE).

MS alone affects around 100,000 people in the UK and 2.5 million people worldwide.

Scientists were able to selectively target the cells that cause autoimmune disease by dampening down their aggression against the body's own tissues while converting them into cells capable of protecting against disease.

This type of conversion has been previously applied to allergies, known as 'allergic desensitisation', but its application to autoimmune diseases has only been appreciated recently.

The Bristol group has now revealed how the administration of fragments of the proteins that are normally the target for attack leads to correction of the autoimmune response.

Most importantly, their work reveals that effective treatment is achieved by gradually increasing the dose of antigenic fragment injected.

In order to figure out how this type of immunotherapy works, the scientists delved inside the immune cells themselves to see which genes and proteins were turned on or off by the treatment.

They found changes in gene expression that help explain how effective treatment leads to conversion of aggressor into protector cells. The outcome is to reinstate self-tolerance whereby an individual's immune system ignores its own tissues while remaining fully armed to protect against infection.

By specifically targeting the cells at fault, this immunotherapeutic approach avoids the need for the immune suppressive drugs associated with unacceptable side effects such as infections, development of tumours and disruption of natural regulatory mechanisms.

Professor David Wraith, who led the research, said: "Insight into the molecular basis of antigen-specific immunotherapy opens up exciting new opportunities to enhance the selectivity of the approach while providing valuable markers with which to measure effective treatment. These findings have important implications for the many patients suffering from autoimmune conditions that are currently difficult to treat."

This treatment approach, which could improve the lives of millions of people worldwide, is currently undergoing clinical development through biotechnology company Apitope, a spin-out from the University of Bristol.



Story Source:

The above post is reprinted from materials provided by University of Bristol. Note: Materials may be edited for content and length.



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2016-08-10 13:05:12
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空白♡
有机会痊愈了?
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2016-08-10 13:44:24
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如涅槃的凤凰
活久见,祈祷成功。
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2016-08-10 13:53:58
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炎炎知夏
仿佛看到了曙光!
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2016-08-10 10:42:31
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小狼女
有机会治愈了?
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2016-08-10 11:35:01
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趁阳光正好
祈祷,快点出来治愈的药!
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2016-08-10 14:29:04
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爱茅茅
好期待呢……那我们可就变成无敌金刚人啦!
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2016-08-10 16:28:49
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觅友_U297666Z3
晚上做梦都是这个病能够治愈了
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2021-05-04 20:45:24
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美,距离的忧伤
科学的力量是无穷的
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2016-08-10 11:54:38
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苏格拉没有底
后续有消息吗
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2021-05-01 09:57:20
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小黑猪
希望赶紧攻克吧
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2016-08-17 20:35:22
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小黑猪
是不是可以治愈了?
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2016-08-21 12:58:25
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菇娘
活久见,所以我们要活下去,希望持续关注进展
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2016-08-10 15:17:05
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小便
自己给自己顶一下。
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2016-08-10 10:24:17
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Melissa
那也就是说能从根源治疗了吧?真希望能快点出成果
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2016-08-10 10:25:01
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meiling 、
期待
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2016-08-10 10:38:02
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•逆光
特效药什么时间可以吃呀,好期待
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2016-08-10 10:46:20
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